MOOC : Vaccinology
- Sciences médicales, Médecine
Informations pratiques sur le MOOC
Description du MOOC
Vaccines are among the most effective public health interventions currently available. Smallpox has been eradicated and polio has almost disappeared worldwide through global vaccine campaigns. Most of the viral and bacterial infections that traditionally affected children have been drastically reduced thanks to national immunization programs in developed countries. Together with antibiotics and clean water, vaccines have increased life expectancy in both high- and low-income countries by eliminating many of the diseases that historically killed millions. It has been estimated that vaccines will have saved ~25 million deaths over 10 yr from 2010 to 2020, which is equivalent to five lives saved per minute. In terms of cost-effectiveness, it is estimated that jQuery1 invested in vaccination results in a jQuery10–44 healthcare saving.
In spite of the success of vaccination in preventing disease and its cost-effectiveness, several challenges remain such as increasing the diversity of the target populations by developing vaccines efficient in pregnant women who will protect their babies at early life, and in the elderly displaying a less efficient immune system to be primed. Besides preventing infectious diseases, a few examples of already available vaccines preventing virus-induced cancers, such as liver cancer due to the hepatitis B virus or cervical cancers due to papilloma viruses, pave the way for further development of anti-cancer vaccines. Recent advances in technology to identify the key antigens to induce efficient protective immunity and large-scale analysis of human immune responses offer to revisit the future of vaccine development in a more global health perspective, taking also into consideration the implementation of new sustainable models for the developing world. This course aims at covering all these aspects to give an overview of the discipline.
Plan du MOOC
Chapter 1 – Introduction to vaccinology, an integrative discipline- part 1
- W1-1: History of vaccines
- W1-2: The legacy of smallpox eradication: Immunization, strategies to control, eliminate or eradicate vaccine-preventable diseases
- W1-3 : Poliovirus : the next successful eradication story ?
- W1-4 : Epidemiology of infectious diseases: prerequisite for decision-making in vaccine development
- W1-5 : Mathematical modeling of infectious diseases transmission
- W1-6 : What a vaccinologist should know about the basic of immunology
- W1-7 : Past, present and future of adjuvants in vaccination
- W1-8 : Measurement of immune responses
Chapter 2 – Introduction to vaccinology, an integrative discipline- part 2
- W2-1 : Immunological memory: the challenge of conferring long-term protection
- W2-2 : Vaccinomics: the future of vaccinology?
- W2-3 : Maternal immunization
- W2-4 : Hurdles to vaccination in early life: revisiting immunological immaturity in human newborns
- W2-5 : Mucosal immunity: advantages and limitations in developing mucosal vaccine
- W2-6 : Antigen discovery: from genomics to proteomics
- W2-7 : Novel strategies for delivering vaccines
Chapter 3 - Preclinical and clinical steps: Basic principles
- W3-1 : Summary of clinical steps for vaccine development
- W3-2 : Decision process in vaccine development
- W3-3 : GMP production: which prerequisites and how to proceed.
- W3-4 : Finding correlates of protection or the « Holy Grail » to avoiding large phase III clinical trials
- W3-5 : Update on human challenge model for evaluation of vaccine efficacy
Chapter 4 - Update of vaccine development for the major infectious diseases
- W4-1 : Success of glycoconjugate vaccines
- W4-2 : Rotavirus vaccines: success and drawbacks.
- W4-3 : HPV: a vaccine against virus-induced cancer
- W4-4 : Influenza vaccines : challenge of making a new vaccine each year
- W4-5 : Tuberculosis: BCG , new vaccines and biomarkers for vaccine trials
Chapter 5 - Vaccines remaining to be developed and implemented
- W5-1 : Introduction and discussion on opportunities and challenges to control respiratory diseases
- W5-2 : Towards the development of a respiratory syncytial virus (RSV) vaccine
- W5-3 : Malaria epidemiology, pathophysiology, immune responses, and vaccine development.
- W5-4 : Dengue epidemiology, pathophysiology, immune responses, and vaccine development
- W5-5 : The burden of diarrheal diseases and prospects for vaccine impact
- W5-6 : Challenges to HIV vaccines
Chapter 6 - Future challenges
- W6-1 : Innovation in future vaccines
- W6-2 : Vaccines for the elderly
- W6-3 : Vaccines for public health emergencies?
- W6-4 : Globalization of vaccine production
- W6-5 : New public/philanthropic private partnerships for effective global health vaccines development: pandemic preparedness & response case study
Please note that the "Qualifying" formula gives the right to a qualifying certification delivered by the Institut Pasteur. There will be no successful follow-up certificate, neither for the "Discovery" formula, nor for the "Qualifying" formula.
- Certificat proposé : oui (payant)
- Attestation proposée : non
- Attendus du MOOC :
This MOOC is taught in english. Videos are subtitled in french and english. We recommend a good scientific background (such as a bachelor of science). The estimated effort of work is 3h per week
- Du cours : Licence restrictive
- Du contenu produit par les participants : Licence restrictive
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Director of research (DR1) at INSERM (Institut national de Santé et de Recherche Médicale)
Microbiologist-immunologist by training, and Director of Research at Institut Pasteur, Paris
Postdoctoral research scientist in the field of virology in the Vaccine Innovation Unit at Institut Pasteur
Health and safety engineer working at the Institut Pasteur